Trospiumdosage
trospium chloride 30 MG / xanomeline 125 MG Oral Capsule [Cobenfy]
Dosage and administration
Assess liver enzymes and bilirubin prior to initiating treatment with COBENFY and as clinically indicated during treatment.
Assess heart rate at baseline and as clinically indicated during treatment with COBENFY.
Recommended starting dosage of COBENFY is 50 mg/20 mg orally twice daily for at least two days, then increase the dosage to 100 mg/20 mg twice daily for at least five days.
Dosage may be increased to 125 mg/30 mg orally twice daily based on patient tolerability and response.
See the full prescribing information for the recommended titration and maximum recommended dosage.
Take at least 1 hour before a meal or at least 2 hours after a meal. Do not open capsules.
Geriatric patients: Recommended starting dosage of COBENFY is 50 mg/20 mg orally twice daily. Consider a slower titration. The maximum recommended dosage is 100 mg/20 mg twice daily.
2.1 Recommended
Testing and Monitoring Prior to Initiation and During Treatment with COBENFY
Assess liver enzymes and bilirubin prior to initiating COBENFY and as clinically indicated during treatment.
Assess heart rate at baseline and as clinically indicated during treatment.
2.2 Recommended
Dosage and Administration The recommended dosage of COBENFY is as follows:
The recommended starting dosage is one 50 mg/20 mg capsule (contains 50 mg of xanomeline and 20 mg of trospium chloride) orally twice daily for at least two days.
Increase the dosage to one 100 mg/20 mg capsule (contains 100 mg of xanomeline and 20 mg of trospium chloride) orally twice daily for at least five days.
The dosage may be increased to one 125 mg/30 mg capsule (contains 125 mg of xanomeline and 30 mg of trospium chloride) orally twice daily based on patient tolerability and response.
Maximum recommended dosage is 125 mg/30 mg orally twice daily. Administer COBENFY orally at least one hour before a meal or at least two hours after a meal. Do not open the capsules.
2.3 Dosage Recommendations in
Geriatric Patients The recommended starting dosage of COBENFY in geriatric patients is one 50 mg/20 mg capsule orally twice daily. Consider a slower titration for geriatric patients. The maximum recommended dosage in geriatric patients is one 100 mg/20 mg capsule twice daily.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective January 16, 2026. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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