Trazodonedosage

Starting dosage: 150 mg orally in divided doses daily. May be increased by 50 mg per day every three to four days.

Maximum dosage: 400 mg per day in divided doses. Administer RALDESY shortly after a meal or light snack. When discontinuing RALDESY, gradually reduce dose.

2.1 Recommended

Dosage The initial dosage of RALDESY for the treatment of MDD in adults is 150 mg daily, taken orally, in divided doses. The dosage should be initiated at a low-dose and increased gradually, depending on clinical response and an tolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage The dose may be increased by 50 mg daily every 3 to 4 days. The maximum recommended dosage for outpatients usually should not exceed 400 mg daily in divided doses. Inpatients (i.e., more severely depressed patients) may be given up to, but not in excess, of 600 mg daily in divided doses. Administer RALDESY orally after a meal or light snack.

2.2 Screen for

Bipolar Disorder Prior to Starting RALDESY Prior to initiating treatment with RALDESY or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania.

2.3 Switching to or from

Monoamine Oxidase Inhibitor Antidepressant At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of RALDESY. In addition, at least 14 days must elapse after stopping RALDESY before starting an MAOI antidepressant.

2.4 Dosage Recommendations for

Concomitant Use with Strong CYP3A4 Inhibitors or Inducers Coadministration with Strong CYP3A4 Inhibitors Consider reducing RALDESY dose based on tolerability when RALDESY is coadministered with a strong CYP3A4 inhibitor. Coadministration with Strong CYP3A4 Inducers Consider increasing RALDESY dose based on therapeutic response when RALDESY is coadministered with a strong CYP3A4 inducer.

2.5 Discontinuation of

Treatment with RALDESY Adverse reactions may occur upon discontinuation of RALDESY. Gradually reduce the dosage rather than stopping RALDESY abruptly whenever possible.