Sotagliflozindosage

Correct volume status before starting INPEFA at 200 mg daily and titrate to 400 mg as tolerated. In patients with decompensated heart failure, begin dosing when patients are hemodynamically stable. Withhold INPEFA at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting.

2.1 Prior to

Initiation of INPEFA Assess volume status and, if necessary, correct volume depletion prior to initiation of INPEFA. Assess renal function prior to initiation of INPEFA and then as clinically indicated. For patients with decompensated heart failure, dosing may begin as soon as the patient is hemodynamically stable, including during hospitalization or urgent outpatient treatment or immediately upon discharge.

2.2 Recommended

Dosage The recommended starting dose of INPEFA is 200 mg orally once daily not more than one hour before the first meal of the day. Up-titrate after at least 2 weeks to 400 mg orally once daily as tolerated. Down-titrate to 200 mg as necessary. Swallow tablets whole. Do not cut, crush, or chew tablets. If a dose of INPEFA is missed by more than 6 hours, take the next dose as prescribed the next day.

2.3 Temporary

Interruption for Surgery Withhold INPEFA at least 3 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Resume INPEFA when the patient is clinically stable and has resumed oral intake.