Somatropindrug info

Somatropin is a human growth hormone (r-hGH) produced by recombinant DNA technology using a mammalian cell line (mouse C127). The protein is comprised of 191 amino acid residues and a molecular weight of 22,125 daltons. The amino acid sequence is identical to that of human growth hormone of pituitary origin. SEROSTIM (somatropin) for injection is a sterile, white to off-white lyophilized powder for subcutaneous use after reconstitution with accompanying diluent. SEROSTIM is supplied as either 4 mg per vial, 5 mg per vial, or 6 mg per vial. Sodium hydroxide or phosphoric acid may have been added to adjust the pH. Each vial contains the following: Vials 4 mg 5 mg 6 mg Component Somatropin 4 mg 5 mg 6 mg Sucrose 27.3 mg 34.2 mg 41 mg Phosphoric acid 0.9 mg 1.2 mg 1.4 mg SEROSTIM 4 mg single-patient-use vials are co-packaged with diluent vials of Bacteriostatic Water for Injection, USP (containing 0.9% benzyl alcohol as a preservative). After each vial is reconstituted with 0.5 mL to 1 mL, the pH is 7.4 to 8.5. SEROSTIM 5 mg single-dose vials are co-packaged with diluent vials of Sterile Water for Injection, USP. After each vial is reconstituted with 0.5 mL to 1 mL, the pH is 6.5 to 8.5. SEROSTIM 6 mg single-dose vials are co-packaged with diluent vials of Sterile Water for Injection, USP. After each vial is reconstituted with 0.5 mL to 1 mL, the pH is 7.4 to 8.5.