Semaglutidedosage

Administer once weekly at any time of day, with or without meals.

Start at 0.25 mg once weekly. After 4 weeks, increase the dosage to 0.5 mg once weekly.

If additional glycemic control is needed, increase the dosage to 1 mg once weekly after at least 4 weeks on the 0.5 mg dose.

If additional glycemic control is needed, increase the dosage to 2 mg once weekly after at least 4 weeks on the 1 mg dosage.

If a dose is missed administer within 5 days of missed dose.

Inject subcutaneously in the abdomen, thigh, or upper arm.

2.1 Important

Administration Instructions

Inspect OZEMPIC visually before use. It should appear clear and colorless. Do not use OZEMPIC if particulate matter and coloration is seen.

Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals.

Inject OZEMPIC subcutaneously to the abdomen, thigh, or upper arm. Instruct patients to use a different injection site each week when injecting in the same body region.

When using OZEMPIC with insulin, instruct patients to administer as separate injections and to never mix the products. It is acceptable to inject OZEMPIC and insulin in the same body region, but the injections should not be adjacent to each other.

2.2 Recommended

Dosage

Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks. The 0.25 mg dosage is intended for treatment initiation and is not effective for glycemic control.

After 4 weeks on the 0.25 mg dosage, increase the dosage to 0.5 mg once weekly.

If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dosage, the dosage may be increased to 1 mg once weekly.

If additional glycemic control is needed after at least 4 weeks on the 1 mg dosage, the dosage may be increased to 2 mg once weekly. The maximum recommended dosage is 2 mg once weekly.

The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours).

If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.