Rosuvastatindosage

Take orally with or without food, at any time of day. Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating CRESTOR, and adjust dosage if necessary.

Adults: Recommended dosage range is 5 to 40 mg once daily.

Pediatric Patients with HeFH: Recommended dosage range is 5 to 10 mg once daily for patients aged 8 to less than 10 years of age, and 5 to 20 mg once daily for patients aged 10 years and older.

Pediatric Patients with HoFH: Recommended dosage is 20 mg once daily for patients aged 7 years and older.

Asian Patients: Initiate at 5 mg once daily. Consider risks and benefits of treatment if not adequately controlled at dosages up to 20 mg once daily. Patients with Severe Renal Impairment (not on hemodialysis): Initiate at 5 mg once daily; do not exceed 10 mg once daily. See full prescribing information for CRESTOR dosage and administration modifications due to drug interactions.

2.1 General

Dosage and Administration Information

Administer CRESTOR orally as a single dose at any time of day, with or without food. Swallow the tablets whole.

Assess LDL-C when clinically appropriate, as early as 4 weeks after initiating CRESTOR, and adjust the dosage if necessary.

If a dose is missed, advise patients not to take an extra dose. Resume treatment with the next dose.

When taking CRESTOR with an aluminum and magnesium hydroxide combination antacid, administer CRESTOR at least 2 hours before the antacid.

2.2 Recommended

Dosage in Adult Patients

The dosage range for CRESTOR is 5 to 40 mg orally once daily.

The recommended dosage of CRESTOR depends on a patient’s indication for usage, LDL-C, and individual risk for CV events.

2.3 Recommended

Dosage in Pediatric Patients Dosage in Pediatric Patients 8 Years of Age and Older with HeFH The recommended dosage range is 5 mg to 10 mg orally once daily in patients aged 8 years to less than 10 years and 5 mg to 20 mg orally once daily in patients aged 10-years and older. Dosage in Pediatric Patients 7 Years of Age and Older with HoFH The recommended dosage is 20 mg orally once daily.

2.4 Recommended

Dosage in Asian Patients Initiate CRESTOR at 5 mg orally once daily due to increased rosuvastatin plasma concentrations. Consider the risks and benefits of CRESTOR when treating Asian patients not adequately controlled at dosages up to 20 mg orally once daily.

2.5 Recommended

Dosage in Patients with Renal Impairment In patients with severe renal impairment (CLcr less than 30 mL/min/1.73 m2) not on hemodialysis, the recommended starting dosage is 5 mg orally once daily and should not exceed 10 mg orally once daily. There are no dosage adjustment recommendations for patients with mild and moderate renal impairment.

2.6 Dosage Modifications

Due to Drug Interactions Table 1 displays dosage modifications for CRESTOR due to drug interactions.

Table 1: CRESTOR Dosage Modifications Due to Drug Interactions Concomitantly Used Drug CRESTOR Dosage Modifications Sofosbuvir/velpatasvir/voxilaprevir or Ledipasvir/sofosbuvir Avoid concomitant use. Gemfibrozil Avoid concomitant use. If use is unavoidable, initiate at 5 mg once daily and do not exceed 10 mg once daily. Tafamidis Avoid concomitant use. If use is unavoidable, initiate at 5 mg once daily and do not exceed 20 mg once daily. Belumosudil Do not exceed 5 mg once daily. Cyclosporine Do not exceed 5 mg once daily. Darolutamide Do not exceed 5 mg once daily. Additional Antiviral Medications ∘ Simeprevir ∘ Dasabuvir/ombitasvir/paritaprevir/ritonavir ∘ Elbasvir/Grazoprevir ∘ Sofosbuvir/Velpatasvir ∘ Glecaprevir/Pibrentasvir ∘ Atazanavir/Ritonavir ∘ Lopinavir/Ritonavir Initiate at 5 mg once daily. Do not exceed 10 mg once daily. Capmatinib Do not exceed 10 mg once daily. Enasidenib Do not exceed 10 mg once daily. Momelotinib Do not exceed 10 mg once daily. Regorafenib Do not exceed 10 mg once daily. Teriflunomide Do not exceed 10 mg once daily. Ticagrelor Do not exceed 20 mg once daily. In patients at increased risk for rhabdomyolysis, consider dosages less than 20 mg per day. Febuxostat Do not exceed 20 mg once daily. Fostamatinib Do not exceed 20 mg once daily.