Pyridostigmineinteractions
pyridostigmine bromide 30 MG Oral Tablet
This is the interactions section of this product’s FDA label — what the manufacturer documented for this drug. It is not a check of your medication list, and a drug missing from it has not been cleared: licensed clinical databases list far more interactions than any single label does. Before combining medicines, ask a pharmacist, who can check everything you take at once and will do it for free.
Named on this label
Every name above is printed in the text below. This is not the full set of drugs that interact with this one — it is the set this manufacturer wrote down.
Drug interactions
Mefloquine: Additive effect on gastrointestinal tract and atrial rate. Anticholinesterase drugs for glaucoma treatment: Additive effects.
Narcotics: Exacerbation of bradycardia possible.
Depolarizing neuromuscular blocking agents: Increased effect.
Non-depolarizing neuromuscular blocking agents: Dose may need to be increased. Aminoglycoside antibiotics, local and some general anesthetics, anti-arrhythmic agents, and other drugs that interfere with neuromuscular transmission should be used cautiously, if at all. Drugs converted to pantothenic acid (e.g., dexpanthenol): Additive effect.
7.1 Mefloquine
Concomitant use of mefloquine and pyridostigmine bromide may have additive effects on the gastrointestinal tract, the most common of which is loose bowels. Additive effects on the atrial rate may also occur with concomitant use of mefloquine and pyridostigmine bromide.
7.2 Other Anticholinesterase
Drugs Concomitant use of anticholinesterase drugs used in the treatment of glaucoma and pyridostigmine bromide may have an additive effect that may cause or exacerbate problems with night vision.
7.3 Narcotics
The bradycardia associated with the use of narcotics may exacerbate pyridostigmine-induced bradycardia.
7.4 Drugs that
Interfere with Neuromuscular Transmission Particular caution should be observed in the administration of depolarizing neuromuscular blocking agents (e.g., succinylcholine) during surgery since the degree of neuromuscular blockade that ensues may be enhanced by previously administered pyridostigmine bromide. Doses of nondepolarizing neuromuscular blocking agents (e.g., pancuronium bromide) may need to be increased in patients previously administered pyridostigmine bromide. Atropine antagonizes the muscarinic effects of pyridostigmine bromide, and this interaction is utilized to counteract the muscarinic symptoms of pyridostigmine bromide toxicity. Anticholinesterase agents are sometimes effective in reversing neuromuscular block induced by aminoglycoside antibiotics. However, aminoglycoside antibiotics, local and some general anesthetics, antiarrhythmic agents, and other drugs that interfere with neuromuscular transmission should be used cautiously, if at all, during treatment with pyridostigmine bromide.
7.5 Drugs Converted to
Pantothenic Acid Concomitant use of drugs that are converted to pantothenic acid in vivo (e.g., dexpanthenol) and pyridostigmine bromide may have additive effects by increasing production of acetylcholine.
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective December 23, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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