Polyethylenedosage

Preparation and Administration: Correct fluid and electrolyte abnormalities before treatment with PEG-3350 and Electrolytes for Oral Solution. Reconstitute PEG-3350 and Electrolytes for Oral Solution with water prior to ingestion. Do not take oral medications within 1 hour before the start or during administration of PEG-3350 and Electrolytes for Oral Solution. Do not take other laxatives while taking PEG-3350 and Electrolytes for Oral Solution. Consume only clear liquids; avoid red and purple liquids. Consume water or other clear liquids up until 2 hours before the time of the colonoscopy. Do not consume solid food within 2 hours before starting PEG-3350 and Electrolytes for Oral Solution.

Adult Dosing Regimen: On day prior to colonoscopy, instruct patients to consume a light breakfast at least 2 hours before starting PEG-3350 and Electrolytes for Oral Solution. Begin the recommended dosage regimen for PEG-3350 and Electrolytes for Oral Solution early in the evening on the day before colonoscopy. Drink reconstituted solution at a rate of 8 ounces every 10 minutes, until 4 liters are consumed, or rectal effluent is clear. For complete information on dosing, preparation and administration, see the full prescribing information.

2.1 Important

Preparation and Administration Instructions Correct fluid and electrolyte abnormalities before treatment with PEG-3350 and Electrolytes for Oral Solution. Reconstitute PEG-3350 and Electrolytes for Oral Solution with water prior to ingestion, do not take undissolved PEG-3350 and Electrolytes for Oral Solution. Do not reconstitute with other liquids and/or add starch-based thickeners to the mixing container. Do not take oral medications within 1 hour before the start of or during administration of PEG-3350 and Electrolytes for Oral Solution. Do not take other laxatives while taking PEG-3350 and Electrolytes for Oral Solution. Consume only clear liquids, avoid red and purple liquids. Patients may consume water or other clear liquids during the bowel preparation and after completion of the bowel preparation up until 2 hours before the time of the colonoscopy. The solution is more palatable if chilled prior to administration. Do not consume solid food within 2 hours before starting PEG-3350 and Electrolytes for Oral Solution. For the best results, do not consume solid food for 3 to 4 hours before drinking the solution. If severe bloating, distention or abdominal pain occurs, slow or temporarily discontinue PEG-3350 and Electrolytes for Oral Solution until the symptoms abate.

2.2 Dosage Regimen

Instruct adult patients that on the day before the colonoscopy procedure, they may consume a light breakfast at least 2 hours before starting PEG-3350 and Electrolytes for Oral Solution. Begin the recommended dosage regiment for PEG-3350 and Electrolytes for Oral Solution early in the evening on the day before colonoscopy. Instruct patients to take PEG-3350 and Electrolytes for Oral Solution in conjunction with clear liquids as follows: 4 Liter Jug Fill the supplied container containing the PEG-3350 and Electrolytes for Oral Solution powder with lukewarm drinking water to the 4-liter fill line

Do not add any other ingredients, flavors, etc. After capping the container, shake vigorously several times to ensure that the ingredients are dissolved. Drink at a rate of 8 ounces every 10 minutes until the entire contents are consumed or the rectal effluent is clear. A loose watery bowel movement should result in approximately one hour. After reconstitution, keep solution refrigerated 2° to 8°C (36° to 46°F). Do not freeze. Use within 48 hours, discard unused portion. Administration via a Nasogastric Tube For patients with a nasogastric tube, administer the reconstituted PEG-3350 and Electrolytes for Oral Solution at a rate of 20 to 30 mL per minute (1.2 to 1.8 liters per hour).