Insulindosage

Only administer subcutaneously (in abdominal wall, thigh, upper arm, or buttocks). Rotate injection sites to reduce risk of lipodystrophy and localized cutaneous amyloidosis. Individualize and adjust dosage based on metabolic needs, blood glucose monitoring results and glycemic control goal. See Full Prescribing Information for dosage adjustments due to drug interactions and patients with renal and hepatic impairment. May use with a meal-time insulin if indicated.

2.1 Important

Administration Instructions Inspect HUMULIN N visually before use. It should not contain particulate matter and should appear uniformly cloudy after mixing. Do not use HUMULIN N if particulate matter is seen. Use HUMULIN N KwikPen with caution in patients with visual impairment that may rely on audible clicks to dial their dose.

2.2 Route of

Administration HUMULIN N should only be administered subcutaneously. Administer in the subcutaneous tissue of the abdominal wall, thigh, upper arm, or buttocks. Rotate injection sites within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis. During changes to a patient's insulin regimen, increase the frequency of blood glucose monitoring. The HUMULIN N KwikPen dials in 1 unit increments. Do not administer HUMULIN N intravenously and do not use HUMULIN N in an insulin infusion pump.

2.3 Dosage Information

Individualize and adjust the dosage of HUMULIN N based on the individual's metabolic needs, blood glucose monitoring results and glycemic control goal. Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness.

2.4 Dosage Adjustment due to

Drug Interactions Dosage adjustment may be needed when HUMULIN N is coadministered with certain drugs. Dosage adjustment may be needed when changing from another insulin to HUMULIN N. Instructions for Mixing with Other Insulins HUMULIN N may be used with a prandial insulin if indicated. HUMULIN N may be mixed with HUMULIN R or HUMALOG before injection. If HUMULIN N is mixed with HUMULIN R, HUMULIN R should be drawn into the syringe first. Injection should occur immediately after mixing. If HUMULIN N is mixed with HUMALOG, HUMALOG should be drawn into the syringe first. Injection should occur immediately after mixing.