Insulindosage

See Full Prescribing Information for important administration instructions.

Inject subcutaneously in abdominal wall, thigh, upper arm, or buttocks and rotate injection sites to reduce the risk of lipodystrophy and localized cutaneous amyloidosis.

Individualize and adjust dosage based on metabolic needs, blood glucose monitoring results and glycemic control goal.

Administer NOVOLIN N once or twice daily.

In patients with type 1 diabetes, NOVOLIN N should generally be used in regimens that include a short-acting insulin.

NOVOLIN N can be mixed with NOVOLIN R.

2.1 Important

Administration Instructions

Always check insulin labels before administration.

NOVOLIN N is a suspension that must be resuspended immediately before use. Resuspension is easier when the insulin has reached room temperature.

To resuspend vial, roll the vial gently in your hands in a horizontal position 10 times until the suspension appears uniformly white and cloudy. Inject immediately.

To resuspend FlexPen, gently move the pen up and down 20 times so the glass ball moves from one end of the cartridge to the other until the suspension appears uniformly white and cloudy. Inject immediately.

Inspect NOVOLIN N visually before use. Do not use NOVOLIN N if discoloration or particulate matter is seen.

Administer NOVOLIN N by subcutaneous injection in the abdominal wall, thigh, upper arm, or buttocks.

Rotate the injection site within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis.

During changes to a patient’s insulin regimen, increase the frequency of blood glucose monitoring.

Do not administer NOVOLIN N intravenously and do not use in an insulin infusion pump.

2.2 Dosage Information •

Individualize and adjust the dosage of NOVOLIN N based on the individual's metabolic needs, blood glucose monitoring results and glycemic control goal.

Administer NOVOLIN N once or twice daily.

In patients with type 1 diabetes, NOVOLIN N should generally be used in regimens that include a short-acting insulin.

Dosage adjustments may be needed with changes in physical activity, changes in meal patterns (i.e., macronutrient content or timing of food intake), changes in renal or hepatic function or during acute illness.

Dosage adjustment may be needed when switching from another insulin to NOVOLIN N.

2.3 Dosage Adjustment due to

Drug Interactions

Dosage adjustment may be needed when NOVOLIN N is co-administered with certain drugs.

2.4 Instructions for

Mixing with Other Insulins

NOVOLIN N can be mixed in the same syringe with NOVOLIN R.

When mixing, the NOVOLIN R should be drawn into the syringe first, followed by the NOVOLIN N. The mixture should be injected immediately after mixing.