Fenofibricdosage

Hypertriglyceridemia: 45 mg to 135 mg once daily. Primary hypercholesterolemia or mixed dyslipidemia: 135 mg once daily.

Renally impaired patients: 45 mg once daily.

Maximum dose: 135 mg once daily. May be taken without regard to food.

2.1 General

Considerations Patients should be placed on an appropriate lipid-lowering diet before receiving fenofibric acid delayed-release capsules and should continue this diet during treatment. Fenofibric acid delayed-release capsules can be taken without regard to meals. Patients should be advised to swallow fenofibric acid delayed-release capsules whole. Do not open, crush, dissolve, or chew capsules. Serum lipids should be monitored periodically.

2.2 Severe Hypertriglyceridemia

The initial dose of fenofibric acid delayed-release capsules are 45 mg to 135 mg once daily. Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. The maximum dose is 135 mg once daily.

2.3 Primary

Hypercholesterolemia or Mixed Dyslipidemia The dose of fenofibric acid delayed-release capsules are 135 mg once daily.

2.4 Impaired

Renal Function Treatment with fenofibric acid delayed-release capsules should be initiated at a dose of 45 mg once daily in patients with mild to moderate renal impairment and should only be increased after evaluation of the effects on renal function and lipid levels at this dose. The use of fenofibric acid delayed-release capsules should be avoided in patients with severely impaired renal function.

2.5 Geriatric

Patients Dose selection for the elderly should be made on the basis of renal function.