Epinephrineinteractions

10 ML epinephrine 0.1 MG/ML Prefilled Syringe

This is the interactions section of this product’s FDA label — what the manufacturer documented for this drug. It is not a check of your medication list, and a drug missing from it has not been cleared: licensed clinical databases list far more interactions than any single label does. Before combining medicines, ask a pharmacist, who can check everything you take at once and will do it for free.

Named on this label

Every name above is printed in the text below. This is not the full set of drugs that interact with this one — it is the set this manufacturer wrote down.

Drug interactions

Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives, and ergot alkaloids. ( 7.1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. ( 7.2) Drugs that increase the arrhythmogenic potential of epinephrine include beta blockers, cyclopropane and halogenated hydrocarbon anesthetics, quinidine, antihistamines, exogenous thyroid hormones, diuretics, and cardiac glycosides. Observe for development of cardiac arrhythmias. ( 7.3) Potassium-depleting drugs, including corticosteroids, diuretics, and theophylline, potentiate the hypokalemic effects of epinephrine. ( 7.4)

7.1 Drugs Antagonizing

Pressor Effects of Epinephrine

α-blockers, such as phentolamine

Vasodilators, such as nitrates

Diuretics

Antihypertensives

Ergot alkaloids

Phenothiazine antipsychotics

7.2 Drugs Potentiating

Pressor Effects of Epinephrine

Sympathomimetics

β-blockers, such as propranolol

Tricyclic anti-depressants

Monoamine oxidase (MAO) inhibitors

Catechol-O-methyl transferase (COMT) inhibitors, such as entacapon

Clonidine

Doxapram

Oxytocin

7.3 Drugs Potentiating

Arrhythmogenic Effects of Epinephrine Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias.

β-blockers, such as propranolol

Cyclopropane or halogenated hydrocarbon anesthetics, such as halothane

Antihistamines

Thyroid hormones

Diuretics

Cardiac glycosides, such as digitalis glycosides

Quinidine

7.4 Drugs Potentiating

Hypokalemic Effects of Epinephrine

Potassium depleting diuretics

Corticosteroids

Theophylline

Text above is quoted in full from the FDA-approved drug label published by openFDA, effective June 8, 2026. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.

This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.

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