Cyclobenzaprineinteractions

24 HR cyclobenzaprine hydrochloride 15 MG Extended Release Oral Capsule

This is the interactions section of this product’s FDA label — what the manufacturer documented for this drug. It is not a check of your medication list, and a drug missing from it has not been cleared: licensed clinical databases list far more interactions than any single label does. Before combining medicines, ask a pharmacist, who can check everything you take at once and will do it for free.

Named on this label

Every name above is printed in the text below. This is not the full set of drugs that interact with this one — it is the set this manufacturer wrote down.

Drug interactions

Based on its structural similarity to tricyclic antidepressants, cyclobenzaprine hydrochloride extended-release capsules may have life-threatening interactions with MAO inhibitors, may enhance the effects of alcohol, barbiturates, and other CNS depressants, may enhance the seizure risk in patients taking tramadol, or may block the antihypertensive action of guanethidine and similarly acting compounds. Postmarketing cases of serotonin syndrome have been reported during combined use of cyclobenzaprine and other drugs, such as SSRIs, SNRIs, TCAs, tramadol, bupropion, meperidine, verapamil, or MAO inhibitors.

MAO Inhibitors: Life-threatening interactions may occur Serotonergic Drugs: Serotonin syndrome has been reported CNS Depressants: Effects of alcohol, barbiturates, and other CNS depressants may be enhanced Tramadol: Seizure risk may be enhanced Guanethidine: Antihypertensive effect may be blocked

Text above is quoted in full from the FDA-approved drug label published by openFDA, effective February 20, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.

This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.

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