Colchicinedrug info

Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for p-(Dipropylsulfamoyl)benzoic acid. The structural formula is represented below: C 13 H 19 NO 4 S M.W.285.36 Probenecid is a white or practically white, fine, crystalline powder. It is soluble in dilute alkali, in alcohol, in chloroform, and in acetone; it is practically insoluble in water and in dilute acids. Colchicine is an alkaloid obtained from various species of Colchicum. The chemical name for Colchicine is (S)-N-(5,6,7,9- tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[α]heptalen-7-yl) acetamide. The structural formula is represented below: C 22 H 25 NO 6 M.W.399.44 Colchicine consists of yellowish white to pale yellow to pale greenish-yellow powder which darken on exposure to light. Colchicine is freely soluble in chloroform. Each tablet for oral administration contains 500 mg of probenecid and 0.5 mg of colchicine. Each tablet also contains the following inactive ingredients: colloidal silicon dioxide, corn starch, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate. FDA approved dissolution test specifications differ from the USP. probenecid-struc.jpg colchicine-struc.jpg