Clarithromycindosage

Adults: clarithromycin extended-release tablets 1 gram every 24 hours for 7–14 days Reduce dose in moderate renal impairment with concomitant atazanavir or ritonavir-containing regimens and in severe renal impairment

2.1 Important

Administration Instructions Clarithromycin extended-release tablets should be taken with food. Swallow clarithromycin extended-release tablets whole; do not chew, break or crush clarithromycin extended-release tablets.

2.2 Adult Dosage

The recommended dosages of clarithromycin extended-release tablets for the treatment of mild to moderate infections in adults are listed in Table 1. Table 1. Adult Dosage Guidelines Clarithromycin Extended-release Tablets Infection Dosage (every 24 hours) Duration (days) Acute bacterial exacerbation of chronic bronchitis 1 gram 7 Acute maxillary sinusitis 1 gram 14 Community-acquired pneumonia 1 gram 7

2.6 Dosage Adjustment in

Patients with Renal Impairment See Table 2 for dosage adjustment in patients with moderate or severe renal impairment with or without concomitant atazanavir or ritonavir-containing regimens. Table 2. Clarithromycin Dosage Adjustments in Patients with Renal Impairment Recommended Clarithromycin Dosage Reduction Patients with severe renal impairment (CL cr of <30 mL/min) Reduce the dosage of clarithromycin by 50% Patients with moderate renal impairment (CL cr of 30 to 60 mL/min) taking concomitant atazanavir or ritonavir-containing regimens Reduce the dosage of clarithromycin by 50% Patients with severe renal impairment (CL cr of <30 mL/min) taking concomitant atazanavir or ritonavir-containing regimens Reduce the dosage of clarithromycin by 75%

2.7 Dosage Adjustment

Due to Drug Interactions Decrease the dose of clarithromycin by 50 % when co-administered with atazanavir. Dosage adjustments for other drugs when co-administered with clarithromycin may be recommended due to drug interactions.

2.1 Important

Administration Instructions Clarithromycin extended-release tablets should be taken with food. Swallow clarithromycin extended-release tablets whole; do not chew, break or crush clarithromycin extended-release tablets.

2.2 Adult Dosage

The recommended dosages of clarithromycin extended-release tablets for the treatment of mild to moderate infections in adults are listed in Table 1. Table 1. Adult Dosage Guidelines Clarithromycin Extended-release Tablets Infection Dosage (every 24 hours) Duration (days) Acute bacterial exacerbation of chronic bronchitis 1 gram 7 Acute maxillary sinusitis 1 gram 14 Community-acquired pneumonia 1 gram 7

2.6 Dosage Adjustment in

Patients with Renal Impairment See Table 2 for dosage adjustment in patients with moderate or severe renal impairment with or without concomitant atazanavir or ritonavir-containing regimens. Table 2. Clarithromycin Dosage Adjustments in Patients with Renal Impairment Recommended Clarithromycin Dosage Reduction Patients with severe renal impairment (CL cr of <30 mL/min) Reduce the dosage of clarithromycin by 50% Patients with moderate renal impairment (CL cr of 30 to 60 mL/min) taking concomitant atazanavir or ritonavir-containing regimens Reduce the dosage of clarithromycin by 50% Patients with severe renal impairment (CL cr of <30 mL/min) taking concomitant atazanavir or ritonavir-containing regimens Reduce the dosage of clarithromycin by 75%

2.7 Dosage Adjustment

Due to Drug Interactions Decrease the dose of clarithromycin by 50 % when co-administered with atazanavir. Dosage adjustments for other drugs when co-administered with clarithromycin may be recommended due to drug interactions.