Citalopramdosage

Administer once daily with or without food.

Initial dosage is 20 mg once daily; after one week may increase to maximum dosage of 40 mg once daily.

Patients greater than 60 years of age, patients with hepatic impairment, and CYP2C19 poor metabolizers: maximum recommended dosage is 20 mg once daily.

When discontinuing citalopram tablets, reduce dosage gradually.

2.1 Recommended

Dosage Administer citalopram tablets once daily, with or without food, at an initial dosage of 20 mg once daily, with an increase to a maximum dosage of 40 mg once daily at an interval of no less than one week. Dosages above 40 mg once daily are not recommended due to the risk of QT prolongation.

2.2 Screen for

Bipolar Disorder Prior to Starting Citalopram Tablets Prior to initiating treatment with citalopram tablets or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania.

2.3 Recommended

Dosage for Specific Populations The maximum recommended dosage of citalopram tablets for patients who are greater than 60 years of age, patients with hepatic impairment, and for CYP2C19 poor metabolizers is 20 mg once daily.

2.4 Dosage Modifications with

Concomitant Use of CYP2C19 Inhibitors The maximum recommended dosage of citalopram tablets when used concomitantly with a CYP2C19 inhibitor is 20 mg once daily.

2.5 Switching

Patients to or from a Monoamine Oxidase Inhibitor Antidepressant At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of therapy with citalopram tablets. Conversely, at least 14 days must elapse after stopping citalopram tablets before starting an MAOI antidepressant.

2.6 Discontinuing

Treatment with Citalopram Tablets Adverse reactions may occur upon discontinuation of citalopram tablets. Gradually reduce the dosage rather than stopping citalopram tablets abruptly whenever possible.