Citalopramdosage

Administer once daily with or without food. Initial dosage is 20 mg once daily; after one week may increase to maximum dosage of 40 mg once daily. Patients greater than 60 years of age, patients with hepatic impairment, and CYP2C19 poor metabolizers: maximum recommended dosage is 20 mg once daily. When discontinuing CELEXA, reduce dosage gradually.

2.1 Recommended

Dosage Administer CELEXA once daily, with or without food, at an initial dosage of 20 mg once daily, with an increase to a maximum dosage of 40 mg once daily at an interval of no less than one week. Dosages above 40 mg once daily are not recommended due to the risk of QT prolongation.

2.2 Screen for

Bipolar Disorder Prior to Starting CELEXA Prior to initiating treatment with CELEXA or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania. 2. 3 Recommended Dosage for Speci fic Populations The maximum recommended dosage of CELEXA for patients who are greater than 60 years of age, patients with hepatic impairment, and for CYP2C19 poor metabolizers is 20 mg once daily [ s ee Warnings and Precautions, Clinical Pharmacology ].

2.4 Dosage Modification s with

Concomitant Use of CYP2C19 Inhibitors The maximum recommended dosage of CELEXA when used concomitantly with a CYP2C19 inhibitor is 20 mg once daily. 2. 5 Switching Patients t o or f rom a Monoamine Oxidase Inhibitor Antidepressant At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of therapy with CELEXA. Conversely, at least 14 days must elapse after stopping CELEXA before starting an MAOI antidepressant. 2. 6 Discontinuing Treatment with C ELEXA Adverse reactions may occur upon discontinuation of CELEXA. Gradually reduce the dosage rather than stopping CELEXA abruptly whenever possible.