Baclofendosage

Baclofen is a concentrated formulation. Verify the dose of the product prior to dispensing. Initiate baclofen with a low dosage, preferably in divided doses, administered orally. Increase gradually based on clinical response and tolerability. The maximum dosage is 80 mg daily (20 mg four times a day). When discontinuing, reduce the dosage slowly.

2.1 Important

Information Baclofen is a concentrated formulation. Verify the strength and the dose of the product prior to prescribing, dispensing, and administering.

2.2 Recommended

Dosage Initiate baclofen with a low dosage, preferably in divided doses, administered orally. The following gradually increasing dosage regimen is suggested, but should be adjusted based on clinical response and tolerability: 1 mL (5 mg) three times a day for three days 2 mL (10 mg) three times a day for three days 3 mL (15 mg) three times a day for three days 4 mL (20 mg) three times a day for three days Additional increases may be necessary up to the maximum recommended dosage of 80 mg daily [4 mL (20 mg) four times a day].

2.3 Administration

Instructions Shake well baclofen oral suspension before administration. Discard unused portion 2 months after first opening. A calibrated measuring device is recommended to measure and deliver the prescribed dose accurately. A household teaspoon or tablespoon is not an adequate measuring device. Nasogastric Tube Administration Baclofen oral suspension can be administered via a nasogastric (NG) tube at sizes 8 French or larger using the following steps: Ensure the NG feeding tube is flushed with appropriate amount of purified water (15 to 30 mL) prior to administration of baclofen oral suspension. Draw the required dose of baclofen oral suspension in the appropriate oral or enteral syringe and administer the dose via the feeding tube. The medication may remain in the dosing syringe for up to 4 hours prior to administration. If residual drug remains in the dosing syringe, draw up purified water into the syringe, shake gently, and administer through the feeding tube. Flush the feeding tube with at least 25 mL of purified water.

2.4 Discontinuation of

Baclofen When discontinuing baclofen, reduce the dosage slowly and avoid abrupt withdrawn from the drug to help minimize the risk of adverse reactions.