Asenapineinteractions
24 HR asenapine 0.158 MG/HR Transdermal System [Secuado]
This is the interactions section of this product’s FDA label — what the manufacturer documented for this drug. It is not a check of your medication list, and a drug missing from it has not been cleared: licensed clinical databases list far more interactions than any single label does. Before combining medicines, ask a pharmacist, who can check everything you take at once and will do it for free.
Named on this label
Every name above is printed in the text below. This is not the full set of drugs that interact with this one — it is the set this manufacturer wrote down.
Drug interactions
Antihypertensive drugs: SECUADO may enhance antihypertensive effects. Monitor blood pressure and adjust dosage of antihypertensive drug accordingly.
Strong CYP1A2 Inhibitors: Consider dose reduction for SECUADO based on clinical response. Paroxetine (CYP2D6 substrate and inhibitor): Reduce paroxetine dose by half.
7.1 Drugs Having
Clinically Important Drug Interactions with SECUADO Table 6: Clinically Important Drug Interactions with SECUADO Antihypertensive Drugs Clinical Implication Because of its α 1 -adrenergic antagonism with potential for inducing hypotension, SECUADO may enhance the effects of certain antihypertensive agents.
Prevention or Management: Monitor blood pressure and adjust dosage of antihypertensive drug accordingly.
Examples: Diuretics, ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers, Alpha-blockers Strong CYP1A2 Inhibitors Clinical Implication Asenapine is metabolized by CYP1A2. Concomitant use of SECUADO with a CYP1A2 inhibitor increases AUC and C max of asenapine.
Prevention or Management: Dosage reduction for SECUADO based on clinical response may be necessary.
Examples: Fluvoxamine, ciprofloxacin, enoxacin CYP2D6 substrates and inhibitors Clinical Implication Asenapine may enhance the inhibitory effects of paroxetine on its own metabolism by CYP2D6. Concomitant use of SECUADO with paroxetine increases paroxetine AUC and C max.
Prevention or Management: Reduce paroxetine dose by half when paroxetine is used in combination with SECUADO.
Examples: Paroxetine
Text above is quoted in full from the FDA-approved drug label published by openFDA, effective January 30, 2025. Matched to this product by RxNorm code. Cross-references to other sections of the full prescribing information have been removed, since they point to a document not shown here. Nothing else is changed: no sentence is shortened, reworded or summarised.
This page reproduces regulatory text for reference. It is not medical advice, and KenyRx is not a pharmacy or a prescriber. Talk to a doctor or pharmacist about whether a medicine is right for you.
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